Prostaglandin F2α synthase promotes oxaliplatin resistance in colorectal cancer through prostaglandin F2α-dependent and F2α-independent mechanism

Figure 3 Prostaglandin F_2α synthase suppresses apoptosis induced by oxaliplatin in colorectal cancer cell lines. A and B: Western blot analysis showed cleaved poly ADP-ribose polymerase and cleaved caspase-3 were assessed in colorectal cancer (CRC) cells or in oxaliplatin-resistant (OR) CRC cells; C and D: Apoptosis of parental and OR CRC cells evaluation by terminal deoxynucleotidyl transferase dUTP nick end labeling assay, scale bar 100 μm; E and F: Apoptosis was measured by the Annexin V-PI staining in parental and OR CRC cells. ^aP < 0.05, ^bP < 0.01, ^cP < 0.001. Oxa: Oxaliplatin; PARP: Poly ADP-ribose polymerase.