Prostaglandin F2α synthase promotes oxaliplatin resistance in colorectal cancer through prostaglandin F2α-dependent and F2α-independent mechanism

Figure 2 Prostaglandin F_2α synthase resists the inhibitory effect of oxaliplatin on colorectal cancer cell proliferation. A: The effects of prostaglandin F_2α synthase (PGFS) overexpression on cell viability in HCT116 and HCT8 cells; B: The effects of PGFS knockdown on cell viability in HCT116-OxR and HCT8-OxR cells; C and D: Western blot analysis showed proliferating cell nuclear antigen levels in parental and oxaliplatin-resistant (OR) colorectal cancer (CRC) cells; E and F: Plate colony formation assay in parental and OR CRC cells. ^aP < 0.05, ^bP < 0.01, ^cP < 0.001, ^dNo significance. PCNA: Proliferating cell nuclear antigen; PGFS: Prostaglandin F_2α synthase; Oxa: Oxaliplatin; IC₅₀: Half-inhibitory concentration.