Diagnostic role of transient elastography in patients with autoimmune liver diseases: A systematic review and meta-analysis

Table 5 Subgroup analysis of sample size and treatment status in prediction of significant fibrosis, advanced fibrosis and cirrhosis in autoimmune hepatitis and primary biliary cholangitis patients

Disease	Parameter	Stage	Subgroup	Sensitivity (95%CI)	Specificity (95%CI)	AUROC (95%CI)
AIH	Sample size	SF	n < 50	0.83 (0.55-0.95)	0.82 (0.65-0.92)	0.85 (0.82-0.88)
			n > 50	0.84 (0.73-0.91)	0.77 (0.63-0.87)	0.87 (0.84-0.90)
		AF	n < 50	0.78 (0.54-0.91)	0.91 (0.78-0.96)	0.92 (0.89-0.94)
			n > 50	0.78 (0.68-0.86)	0.87 (0.73-0.94)	0.88 (0.84-0.90)
		Cirrhosis	n < 50	0.90 (0.65-0.98)	0.92 (0.74-0.98)	0.96 (0.94-0.97)
			n > 50	0.88 (0.82-0.93)	0.93 (0.86-0.96)	0.92 (0.89-0.94)
	Treatment status	SF	Post	0.78 (0.44-0.94)	0.76 (0.60-0.86)	0.79 (0.75-0.82)
		AF	Post	0.83 (0.66-0.93)	0.96 (0.84-0.99)	0.93 (0.91-0.95)
		Cirrhosis	Post	0.91(0.77-0.97)	0.97 (0.73-1.00)	0.94 (0.91-0.95)
	Cutoff value	SF	5.80-6.27	0.87 (0.81-0.92)	0.69 (0.60-0.77)	0.86 (0.83-0.89)
			6.40-9.10	0.82 (0.75-0.88)	0.89 (0.74-0.96)	0.92 (0.89-0.94)
		AF	9.00-11.00	0.83 (0.69-0.91)	0.92 (0.73-0.98)	0.88 (0.85-0.91)
			8.18-12.10	0.77 (0.71-0.83)	0.85 (0.80-0.89)	0.88 (0.85-0.90)
		Cirrhosis	11.00-12.67	0.89 (0.82-0.94)	0.88 (0.81-0.93)	0.92 (0.94-0.96)
			11.00-19.00	0.88 (0.82-0.93)	0.92 (0.88-0.95)	0.90 (0.87-0.92)
PBC	Sample size	SF	n < 100	0.81 (0.48-0.95)	0.78 (0.60-0.89)	0.82 (0.79-0.86)
			n > 100	0.83 (0.68-0.92)	0.98 (0.74-1.00)	0.97 (0.95-0.98)
		AF	n < 100	0.90 (0.85-0.94)	0.88 (0.78-0.94)	0.91 (0.88-0.93)
			n > 100	0.81 (0.64-0.91)	0.88 (0.75-0.94)	0.91 (0.88-0.93)
		Cirrhosis	n < 100	0.82 (0.67-0.91)	0.94 (0.80-0.99)	0.86 (0.82-0.89)
			n > 100	0.91 (0.76-0.97)	0.97 (0.90-0.99)	0.94 (0.92-0.96)
	Treatment status	SF	Post	0.89 (0.70-0.97)	0.98 (0.41-1.00)	0.97 (0.95-0.98)
		AF	Post	0.85 (0.68-0.94)	0.92 (0.63-0.99)	0.93 (0.91-0.95)
		Cirrhosis	Post	0.90 (0.71-0.97)	0.96 (0.74-1.00)	0.94 (0.92-0.96)
	Cutoff value	AF	6.75-7.60	0.80 (0.73-0.86)	0.81 (0.76-0.86)	0.88 (0.85-0.91)
			9.60-10.70	0.91 (0.84-0.95)	0.82 (0.77-0.87)	0.92 (0.89-0.94)
			11.90-17.90	0.75 (0.60-0.86)	0.94 (0.88-0.97)	0.93 (0.91-0.95)
		Cirrhosis	11.40-14.40	0.84 (0.69-0.93)	0.94 (0.90-0.97)	0.96 (0.94-0.97)
			14.40-16.90	0.88 (0.72-0.97)	0.99 (0.96-1.00)	0.99 (0.98-1.00)

95%CI: 95% confidence interval; AF: Advanced fibrosis; AIH: Autoimmune hepatitis; AUROC: Area under the receiver operator curve; PBC: Primary biliary cholangitis; SF: Significant fibrosis.