Diagnostic role of transient elastography in patients with autoimmune liver diseases: A systematic review and meta-analysis

Table 4 Heterogeneity of all the included studies

		Fibrosis stage	Threshold heterogeneity		Non-threshold heterogeneity
			r	P value	I2 (%)	P value
AIH	TE	SF	0.176	0.651	82.9	0
		AF	-0.429	0.337	93.8	0
		Cirrhosis	0.321	0.482	56.59	0.03
	APRI	SF	1.0	0	62.34	0.05
		AF	0.717	0.02	71.94	0
		Cirrhosis	0.714	0.111	90.93	0
	FIB-4	SF	0.70	0.188	46.81	0.11
		AF	0.627	0.039	98.29	0
		Cirrhosis	-0.029	0.957	88.98	0
	AAR	AF	0.857	0.014	36.46	0.16
	SWE	Cirrhosis	0	1.0	61.97	0.05
PBC	TE	SF	-0.10	0.873	99.99	0
		AF	0.195	0.590	100	0
		Cirrhosis	-0.726	0.027	93.77	0
	APRI	SF	1.0	0	99.9	0
		AF	0.209	0.454	100	0
		Cirrhosis	-0.657	0.156	100	0
	FIB-4	AF	0.418	0.156	100	0
		Cirrhosis	0.029	0.957	100	0
	AAR	AF	0.60	0.208	96.05	0
		Cirrhosis	0.40	0.60	95.37	0
	M2BP	AF	0	1.0	99.24	0
	RPR	AF	0	1.0	94.49	0
PSC	TE	Cirrhosis	0.80	0.20	50.07	0.11

AAR: Aspartate aminotransferase to alanine aminotransferase ratio; AF: Advanced fibrosis; AIH: Autoimmune hepatitis; APRI: Aspartate aminotransferase to platelet ratio index; FIB-4: Fibrosis-4 index; M2BP: Mac-2-binding protein; PBC: Primary biliary cholangitis; PSC: Primary sclerosing cholangitis; RPR: Red cell distribution width to platelet ratio; SF: Significant fibrosis; SWE: Shear wave elastography; TE: Transient elastography.