Diagnostic role of transient elastography in patients with autoimmune liver diseases: A systematic review and meta-analysis

Table 3 Summary area under the receiver operator curve and diagnostic odds ratio of noninvasive methods for prediction of significant fibrosis, advanced fibrosis and cirrhosis in autoimmune liver diseases patients

Disease	Diagnostic model/Stage	No. of studies (patients)	AUROC (95%CI)	DOR (95%CI)
AIH	APRI
	SF	4 (383)	0.67 (0.63-0.71)	3.87 (2.1-7.3)
	AF	10 (917)	0.71 (0.67-0.75)	3.85 (2.8-5.3)
	Cirrhosis	6 (543)	0.71 (0.67-0.75)	3.77 (2.2-6.4)
	FIB-4
	SF	5 (459)	0.74 (0.70-0.78)	5.11 (3.1-8.5)
	AF	11 (962)	0.73 (0.69-0.76)	4.04 (2.4-6.8)
	Cirrhosis	6 (543)	0.72 (0.68-0.76)	5.48 (2.4-12.6)
	TE
	SF	9 (523)	0.84 (0.80-0.87)	16.83 (8.8-32.2)
	AF	7 (460)	0.88 (0.85-0.90)	25.14 (9.7-65.3)
	Cirrhosis	7 (415)	0.90 (0.87-0.92)	91.77 (40.1-201.2)
	AAR
	AF	6 (410)	0.73 (0.69-0.77)	4.94 (3.2-7.8)
	2D-SWE
	Cirrhosis	4 (297)	0.91 (0.89-0.94)	30.68 (15.7-59.9)
PBC	APRI
	SF	4 (584)	0.77 (0.73-0.80)	6.27 (3.5-11.2)
	AF	15 (1589)	0.70 (0.66-0.74)	3.67 (2.3-5.9)
	Cirrhosis	6 (852)	0.83 (0.79-0.86)	14.55 (1.9-113.8)
	FIB-4
	AF	13 (1296)	0.79 (0.75-0.82)	7.13 (4.0-12.8)
	Cirrhosis	6 (852)	0.88 (0.85-0.91)	29.79 (5.9-150.3)
	TE
	SF	5 (446)	0.93 (0.91-0.95)	74.45 (12.2-455.5)
	AF	10 (880)	0.93 (0.90-0.95)	41.84 (19.3-91.0)
	Cirrhosis	6 (483)	0.91 (0.88-0.93)	134.83 (33.0-551.8)
	AAR
	AF	6 (559)	0.74 (0.70-0.78)	4.13 (2.0-8.6)
	Cirrhosis	4 (407)	0.88 (0.84-0.90)	25.29 (9.0-70.9)
	RPR
	AF	4 (362)	0.53 (0.49-0.58)	7.98 (4.0-15.8)
	M2BP
	AF	4 (370)	0.86 (0.82-0.88)	13.17 (4.1-42.4)
PSC	TE
	Cirrhosis	4 (207)	0.95 (0.93-0.97)	70.59 (15.4-322.7)

2D-SWE: Two-dimensional shear wave elastography; 95%CI: 95% confidence interval; AAR: Aspartate aminotransferase to alanine aminotransferase ratio; AF: Advanced fibrosis; AIH: Autoimmune hepatitis; APRI: Aspartate aminotransferase to platelet ratio index; AUROC: Area under the receiver operator curve; DOR: Diagnostic odds ratio; FIB-4: Fibrosis-4 index; PBC: Primary biliary cholangitis; PSC: Primary sclerosing cholangitis; RPR: Red cell distribution width to platelet ratio; SF: Significant fibrosis; TE: Transient elastography.