Risk assessment of venous thromboembolism in inflammatory bowel disease by inherited risk in a population-based incident cohort

doi:10.3748/wjg.v29.i39.5494

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Oct 21, 2023 (publication date) through Dec 22, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Oct 21, 2023; 29(39): 5494-5502
Published online Oct 21, 2023. doi: 10.3748/wjg.v29.i39.5494

Table 2 Association of venous thromboembolism risk with F5/F2 mutations and polygenic score in the UK Biobank

	IBD patients, n (%)	Incident VTE, n (%)	HR (95%CI)¹	P value
FVL/F2 carrier status
Non-carriers	7701/8210 (93.8)	332/7701 (4.31)	Ref.
FVL carriers	351/8210 (4.28)	37/351 (10.54)	2.27 (1.61-3.21)	2.84E-06
F2 carriers	163/8210 (1.99)	10/163 (6.13)	1.29 (0.69-2.43)	0.43
Any FVL/F2 carriers	509/8210 (6.2)	46/509 (9.04)	1.94 (1.42-2.65)	3.27E-05
PGS_non-F5/F2 decile
Bottom	821/8210 (10)	13/821 (1.58)	0.36 (0.21-0.63)	3.12E-04
Intermediate	6568/8210 (80)	295/6568 (4.49)	Ref.
Top	821/8210 (10)	70/821 (8.53)	1.98 (1.52-2.57)	3.26E-07

¹HR adjusted for gender, body mass index, and genetic background. The time in survival analysis was from inflammatory bowel disease to event.

IBD: Inflammatory bowel disease; VTE: Venous thromboembolism; 95%CI: 95% confidence interval; HR: Hazard ratio.

Citation: Rifkin AS, Shi Z, Wei J, Zheng SL, Helfand BT, Cordova JS, Biank VF, Tafur AJ, Khan O, Xu J. Risk assessment of venous thromboembolism in inflammatory bowel disease by inherited risk in a population-based incident cohort. World J Gastroenterol 2023; 29(39): 5494-5502
URL: https://www.wjgnet.com/1007-9327/full/v29/i39/5494.htm
DOI: https://dx.doi.org/10.3748/wjg.v29.i39.5494