Sequence of events leading to primary biliary cholangitis

Figure 2 Central role of ductular reaction in the progression of primary biliary cholangitis. Ductular reaction contributes to the activation of hepatic stellate cells and simultaneously favours a cell senescent phenotype. These events support the ductopenic/cirrhotic evolution of liver tissue during this cholestatic disease. PBC: Primary biliary cholangitis; SASP: Senescence-associated secretory phenotype.