New insights into the pathogenesis of primary biliary cholangitis asymptomatic stage

doi:10.3748/wjg.v29.i37.5292

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Oct 7, 2023 (publication date) through Nov 28, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Oct 7, 2023; 29(37): 5292-5304
Published online Oct 7, 2023. doi: 10.3748/wjg.v29.i37.5292

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Figure 1 Schematic of bicarbonate secretion by small and large cholangiocytes. AE2: Chloride/bicarbonate anion exchanger 2; TMEM16A: Transmembrane 16A chloride channels; ATP: Adenosine triphosphate; P2YR: Purinergic receptor family; InsP₃: Inositol-1,4,5-trisphosphate; InsP₃R3: Inositol-1,4,5-trisphosphate receptor type 3; ER: Endoplasmic reticulum; SR: Secretin receptor; cAMP: Cyclic adenosine monophosphate; Ach: Acetylcholine; CFTR: Cystic fibrosis transmembrane conductance regulator; M3R: Muscarinic acetylcholine M3 receptor; HCO₃^-: Bicarbonate; Cl^-: Chloride; Ca²⁺: Calcium.

Citation: Reshetnyak VI, Maev IV. New insights into the pathogenesis of primary biliary cholangitis asymptomatic stage. World J Gastroenterol 2023; 29(37): 5292-5304
URL: https://www.wjgnet.com/1007-9327/full/v29/i37/5292.htm
DOI: https://dx.doi.org/10.3748/wjg.v29.i37.5292