Curcumin alleviated dextran sulfate sodium-induced colitis by recovering memory Th/Tfh subset balance

Figure 6 Curcumin inhibits JAK1/STAT3/SOCS signaling pathway-related proteins in ulcerative colitis mice. A: Western blotting of the major proteins in the JAK1/STAT3/SOCS signaling pathway, such as JAK1, p-JAK1, STAT3, p-STAT3, NF-κB p65, SOCS-1, and SOCS-3. Tubulin served as the reference protein in this study; B-J: Quantitative evaluations of JAK1 (B), p-JAK1 (C), JAK1/p-JAK1 (D), STAT3 (E), p-STAT3 (F), STAT3/p-STAT3 (G), SOCS-1 (H), SOCS-3 (I), and NF-κB p65 (J). Data of each group are expressed as the mean ± SD. The differences were statistically significant when compared with the Ctrl group (^aP < 0.05, ^bP < 0.01). Differences were statistically significant with the dextran sulfate sodium group (^cP < 0.05, ^dP < 0.01). Cur: Curcumin; DSS: Dextran sulfate sodium.