Curcumin alleviated dextran sulfate sodium-induced colitis by recovering memory Th/Tfh subset balance

Figure 4 Memory T helper 10/memory follicular T helper 10 cell subpopulation levels in ulcerative colitis mice. A: Typical flow cytometry patterns of the spleen CD4⁺ cells; B: Typical flow cytometry patterns were observed in the spleen; C: Typical flow cytometry patterns and histograms in the spleen of CD4⁺ CCR7^- cells; D and E: CD4⁺ IL-10⁺ (Th10) cells; F and G: CD4⁺ CXCR5⁺ IL-10⁺ (Tfh10) cells; H and I: CD4⁺ CCR7^-IL-10⁺ (mTh10) cells; J and K: CD4⁺ CCR7^-CXCR5⁺ IL-10⁺ (mTfh10) cells. Data are expressed as the mean ± SD (n = 8). The differences were statistically significant when compared with the Ctrl group (^aP < 0.05, ^bP < 0.01). Differences were statistically significant with the dextran sulfate sodium group (^cP < 0.05, ^dP < 0.01). Cur: Curcumin; DSS: Dextran sulfate sodium.