Lowering the threshold of alanine aminotransferase for enhanced identification of significant hepatic injury in chronic hepatitis B patients

Figure 3 The alanine aminotransferase treatment threshold was lowered to the American Association for the Study of Liver Diseases 2018 treatment criteria (35 U/L for males and 25 U/L for females). A: Among the 794 chronic hepatitis B virus infections, 27.8% (221/794) of patients were above the American Association for the Study of Liver Diseases criteria; B: Comparison of the proportions of patients exceeding the alanine aminotransferase (ALT) threshold in different groups; C: A total of 43.1% (247/573) of patients below the ALT threshold had significant liver inflammation (≥ G2); D: The proportion of significant hepatic injury (SHI) in patients below the ALT threshold was 51.3%. Comparison of the proportions of SHI in each group. ALT: Alanine aminotransferase; NS: Not significant. ^aP < 0.05, ^bP < 0.01, ^cP < 0.001.