Clinical characteristics and outcome of autoimmune pancreatitis based on serum immunoglobulin G4 level: A single-center, retrospective cohort study

doi:10.3748/wjg.v29.i35.5125

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Cohort Study

World J Gastroenterol. Sep 21, 2023; 29(35): 5125-5137
Published online Sep 21, 2023. doi: 10.3748/wjg.v29.i35.5125

Table 3 Laboratory results of patients in the two groups (n, %)

	Normal group (n = 65)	Abnormal group (n = 148)	P value
Hb (g/L)	126.3 ± 16.8	126.8 ± 14.6	0.828
WBC (× 10⁹/L)	6.5 ± 2.2	5.8 ± 1.8	0.026^a
NEUT	61.8 ± 11.1	56.1 ± 10.3	0.001^a
LY	26.8 ± 9.8	29.2 ± 8.2	0.071
EOS	3.9 ± 3.4	6.2 ± 5.4	0.001^a
BASO	0.6 ± 0.4	0.8 ± 0.5	0.003^a
PLT (× 10⁹/L)	212.9 ± 83.3	218.6 ± 75.0	0.621
TP (g/L)	67.2 ± 7.5	72.5 ± 7.9	< 0.001^a
ALB (g/L)	39.4 ± 5.8	36.7 ± 4.6	0.001^a
TT (s)	16.9 ± 1.2	17.4 ± 1.6	0.012^a
IgG1 (mg/dL)	872.6 ± 371.8	935.8 ± 319.9	0.045^a
IgG2 (mg/dL)	450.4 ± 174.0	638.6 ± 241.6	< 0.001^a
IgG3 (mg/dL)	42.70 ± 43.37	53.6 ± 58.4	0.034^a
IgG4 (mg/dL)	252.7 ± 106.6	1420.5 ± 1110.9	< 0.001^a
IgE (IU/mL)	231.7 ± 352.5	635.6 ± 958.1	0.002^a
IgG (mg/dL)	1323.6 ± 503.9	2062.1 ± 918.9	< 0.001^a
FLC-κ (mg/dL)	306.1 ± 99.7	569.6 ± 252.5	< 0.001^a
FLC-λ (mg/dL)	176.4 ± 63.4	282.5 ± 124.5	< 0.001^a
C3 (mg/dL)	119.0 ± 45.7	100.6 ± 36.2	0.050
ESR (mm/h)	21.1 ± 20.1	43.4 ± 28.6	0.002^a
ANA (positive)	5 (12.5)	19 (20.0)	0.298
CA19-9 (abnormal)	33 (53.0)	73 (52.0)	0.887

^aP < 0.05 vs normal group. Hb: Hemoglobin; WBC: White blood cell; NEUT: Neutrophil; LY: Lymphocyte; EOS: Eosinophil; PLT: Hemoglobin; BASO: Basophil; TP: Total protein; ALB: Albumin; TT: Thrombin time; FLC: Free light chain; ANA: Antinuclear antibody; CA19-9: Carbohydrate associated antigen 19-9; Ig: Immunoglobulin; C3: Complement C3; ESR: Erythrocyte sedimentation rate.

Citation: Zhou GZ, Zeng JQ, Wang L, Liu M, Meng K, Wang ZK, Zhang XL, Peng LH, Yan B, Pan F. Clinical characteristics and outcome of autoimmune pancreatitis based on serum immunoglobulin G4 level: A single-center, retrospective cohort study. World J Gastroenterol 2023; 29(35): 5125-5137
URL: https://www.wjgnet.com/1007-9327/full/v29/i35/5125.htm
DOI: https://dx.doi.org/10.3748/wjg.v29.i35.5125