Developments and challenges in neoadjuvant therapy for locally advanced pancreatic cancer

Table 1 Definitions of locally advanced pancreatic cancer by different groups

Group	Definition
	Arterial	Venous
NCCN[14]	Head/uncinate process:	Unreconstructible SMV/PV due to tumor involvement or occlusion (can be due to tumor or bland thrombus)
	Solid tumor contact > 180° with the SMA or CA
	Body and tail
	Solid tumor contact of > 180° with the SMA or CA
	Solid tumor contact with the CA and aortic involvement
IAP[15]	Tumor contact/invasion of 180 or more degree CHA	Bilateral narrowing/occlusion, exceeding the inferior border of the duodenum
	Tumor contact/invasion showing tumor contact/invasion of the PHA and/or CA
CMA[5]	Head	Unreconstructible SMV/PV due to tumor involvement or occlusion (can be due to tumor or bland thrombus). The tumor extensively involves the distal jejunal drainage branch of the superior mesenteric vein
	Solid tumor contact of > 180° with the SMA or CA
	Body and tail
	Solid tumor contact of > 180° with the SMA or CA
	Solid tumor contact with the CA and aortic involvement

CA: Celiac axis; CHA: Common hepatic artery; CMA: Chinese Medical Association; IAP: International Association of Pancreatology; NCCN: National Comprehensive Cancer Network; PHA: Proper hepatic artery; PV: Portal vein; SMA: Superior mesenteric artery; SMV: Superior mesenteric vein.