Role of biochemical markers and autoantibodies in diagnosis of early-stage primary biliary cholangitis

Table 1 Clinical and laboratory data of patients with primary biliary cholangitis

	Early-stage (stages I + II; n = 48)	Stage III (n = 22)	Stage IV (n = 12)	P value
ALT	53.5 (29.5-124.5)	54.0 (30.0-127.6)	80.0 (42.8-127.4)	0.639
AST	53.5 (34.0-97.3)a	68.5 (39.6-114.1)	112.2 (81.1-136.3)	0.009
TBA	9.0 (3.6-36.4)a	18.0 (7.0-45.1)	28.2 (18.0-111.5)	0.011
TBIL	15.4 (11.2-27.8)a	16.7 (13.7-24.2)a	61.2 (28.1-114.3)	0.002
DBIL	5.2 (3.7-16.0)a	8.7 (2.5-12.4)a	42.3 (15.8-67.3)	0.003
ALB	42.1 (38.3-44.8)a	39.3 (36.5-42.5)	35.8 (30. 5-41.0)	0.005
A/G	1.2 (1.1-1.4)a	1.0 (0.9-1.3)	0.9 (0.7-1.1)	0.001
ALP	200.4 (117.8-414.0)a	292.5 (162.0-421.3)	463.5 (329.6-770.5)	0.008
GGT	289.0 (133.0-668.8)	532.0 (326. 5-764.3)	336.5 (264.0-648.0)	0.070
CHO	5.8 (4.6-6.9)	6.2 (5.1-7.5)	6.8 (4.9-7.0)	0.509
TG	1.3 (1.0-1.8)	1.6 (1.2-2.1)a	1.1 (0.8-1.5)	0.019
IgG	16.7 ± 4.6	17.6 ± 6.7	20.6 ± 7.9	0.056
IgA	2.9 (2.1-3.3)	3.5 (2.5-4.7)	3.4 (2.4-4.4)	0.031
IgM	3.4 (1.8-5.1)	3.7 (2.1-5.0)	3.7 (1.9-6.8)	0.967
C3	1.4 (1.2-1.6)	1.6 (1.3-1.8)	1.2 (1.0-1.7)	0.126
C4	0.2 (0.2-0.3)	0.2 (0.2-0.3)	0.2 (0.2-0.3)	0.963

^aP < 0.05 indicates statistically significant difference compared to stage IV.

ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; TBA: Total bile acid; ALP: Alkaline phosphatase; GGT: γ-glutamyl transferase; ALB: Albumin; A/G: Albumin/globulin; TBIL: Total bilirubin, DBIL: Direct bilirubin; CHO: Cholesterol; TG: Triglycerides; IgG: Immunoglobulin G; IgM: Immunoglobulin M; IgA: Immunoglobulin A; C3: Complement 3; C4: Complement 4.