Diabetes exacerbates inflammatory bowel disease in mice with diet-induced obesity

Figure 5 Body weight, blood glucose, and dextran sodium sulfate colitis activity in diabetic diet-induced obese mice on antidiabetic treatment. A: Body weight; B: Blood glucose; C: Change in blood glucose in high-fat diet-fed mice that received either vehicle (Veh) or streptozotocin to induce diabetes and were then treated with the sodium-glucose cotransporter-2 inhibitor dapagliflozin or Veh, prior to dextran sodium sulfate (DSS) colitis onset; D: Amount of DSS consumed during the DSS course; E: DSS colitis disease activity index scores through the 7 d course of DSS; F: DSS colitis disease activity index scores quantified on days 2, 6, and 7. n = 7-8 per group, mean ± standard error of the mean. DSS: Dextran sodium sulfate; Veh: Vehicle; STZ: Streptozotocin; HFD: High-fat diet.