Diabetes exacerbates inflammatory bowel disease in mice with diet-induced obesity

Figure 2 Clinical and pathological outcomes of dextran sodium sulfate colitis in diabetic diet-induced obese mice. A: Clinical disease activity index scores in high-fat diet (HFD)-fed mice that received either vehicle (Veh) or streptozotocin (STZ) to induce diabetes prior to the dextran sodium sulfate (DSS) course; B: Quantification on days 2 and 7; C: Colon length; D: Spleen weight-to-body weight ratio on day 7 of DSS; E: Histologic scoring of DSS damage in colonic tissues from HFD-fed normoglycemic Veh and hyperglycemic STZ mice treated with DSS; F: Representative × 20 images of normoglycemic Veh mice; G: Hyperglycemic STZ mice. n = 7-8 per group, mean ± standard error of the mean. In (A), ^aP < 0.05, ^dP < 0.0001 and comparison noted in (A) is between HFD/Veh/DSS and HFD/STZ/DSS groups for days 2-7 of DSS. DSS: Dextran sodium sulfate; Veh: Vehicle; STZ: Streptozotocin; HFD: High-fat diet.