Angiotensin-converting enzyme 2 improves liver fibrosis in mice by regulating autophagy of hepatic stellate cells

Figure 2 Effect of rAAV-Angiotensin-converting enzyme 2 treatment on the levels of multiple biomarkers in mouse serum. A: The level of platelet-derived growth factor BB in each group was measured by Luminex assay; B: The level of angiopoietin-2 in each group was measured by Luminex assay; C: The level of vascular endothelial growth factor in each group was measured by Luminex assay; D: The level of interleukin-10 in each group was measured by Luminex assay; E: The level of angiotensin II in each group was measured by Enzyme Linked Immunosorbent Assay; F: The level of angiotensin- (1-7) in each group was measured by Enzyme Linked Immunosorbent Assay. ^aP < 0.001 vs Control; ^bP < 0.001 vs CCl₄; ^cP < 0.001 vs rAAV-ACE2 + CCl₄; ^dP < 0.01 vs rAAV-ACE2 + CCl₄; ^eP < 0.01 vs Control; ^fP < 0.05 vs rAAV-ACE2 + CCl₄. Rapa: Rapamycin; PDGF-BB: Platelet-derived growth factor BB; VEGF: Vascular endothelial growth factor; IL-10: Interleukin-10; ACE2: Angiotensin-converting enzyme 2.