Non-coding RNAs: The potential biomarker or therapeutic target in hepatic ischemia-reperfusion injury

Table 3 Long non-coding RNAs and their function in hepatic ischemia-reperfusion injury

lncRNAs	Change	Targets	Effect on HIRI	Models	Ref.
TUG1	Up	Brg1, miR-194/SIRT1	Alleviate	Mice, AML12 cells, WRL-68 cells	[133,144]
SNHG1	Up	miR-186-5p/YY1	Alleviate	AML12 cells	[145]
NEAT1	Up	-	Aggravate	HL7702 cells	[134]
Gm4419	Up	miR-455/SOX6 axis	Aggravate	Rats and BRL-3A	[138]
AK139328	Up	Akt signaling pathway and NF-κB	Aggravate	Mice and primary mouse hepatocyte	[130]
AK054386	Up	miR-199	Aggravate	Mice and BNL-CL2 cells	[140]
HOTAIR	Up	miR-20b-5p/ATG7	Aggravate	Mice and primary mouse hepatocyte	[141]
MALAT1	Up	HMGB1-TLR4	Aggravate	HL7702 cells	[135]
Hnf4αos	Up	Hnf4α/miR-23a	Aggravate	Human, mice, primary mouse hepatocyte and L02 cells	[136]
KCNQ1OT1	Up	miR-142a-3p/HMGB1	Aggravate	Mice and primary mouse hepatocyte	[15]
CCAT1	Down	caspase-3, cyclin D1	Aggravate	HL7702 cells	[139]
MEG3	Down	miR-34a/Nrf2	Aggravate	Mice and HL7702 cells	[137]

lncRNAs: Long non-coding RNAs; HIRI: Hepatic ischemia-reperfusion injury.