Copyright
©The Author(s) 2023.
World J Gastroenterol. Aug 28, 2023; 29(32): 4900-4911
Published online Aug 28, 2023. doi: 10.3748/wjg.v29.i32.4900
Published online Aug 28, 2023. doi: 10.3748/wjg.v29.i32.4900
WD alone (n = 812) | With previous HBV (n = 84) | With current HBV (n = 19) | P1 | P2 | |
Sex | |||||
Male (n, %) | 467 (57.5) | 46 (61.9) | 12 (63.2) | 0.509 | 0.797 |
Female (n, %) | 345 (42.5) | 32 (38.1) | 7 (36.8) | 0.509 | 0.797 |
Mean age (yr) | 18.8 ± 12.0 | 33. ± 15.9 | 25.0 ± 13. | 0.000 | 0.031 |
Diagnosis delay | 12.1 ± 21.3 | 13.7 ± 26.1 | 34.6 ± 53.5 | 0.542 | 0.000 |
Phenotype | |||||
Pure H (n, %) | 564 (69.5) | 63 (75.0) | 17 (89.5) | 0.352 | 0.104 |
H and N (n, %) | 195 (24.40) | 21 (25.60) | 2 (10.5) | 0.352 | 0.104 |
Pure N (n, %) | 35 (4.3) | 0 (0.0) | 0 | ||
Others (n, %) | 18 (2.2) | 0 | 0 | ||
Copper metabolic | |||||
KF positive | 67.6% | 84.1% | 78.9% | 0.102 | 0.456 |
Ceruloplasmin | 64.1 ± 46.0 | 97.1 ± 60.3 | 105.0 ± 61.6 | 0.000 | 0.000 |
Urinary copper | 502.4 ± 1030.5 | 916.3 ± 245.8 | 767.7 ± 1165.0 | 0.005 | 0.323 |
Urinary Cu after PC | 2236.4 ± 1582.1 | 2283.7 ± 1287.8 | 2793.8 ± 3157.5 | 0.842 | 0.144 |
Hepatic Cu | 832.2 ± 457.7 | 680.1 ± 407.7 | 789.0 ± 338.2 | 0.191 | 0.767 |
Mean WD score | 7.4 ± 2.3 | 8.0 ± 2.2 | 7.8 ± 2.3 | 0.124 | 0.412 |
Biochemical | |||||
ALT (IU/L) | 86.2 ± 105.7 | 63.3 ± 51.0 | 94.6 ± 71.1 | 0.0051 | 0.722 |
AST (IU/L) | 84.25 ± 90.3 | 90.47 ± 70.4 | 125.3 ± 80.5 | 0.0532 | 0.058 |
Albumin (g/L) | 38.5 ± 8.3 | 32.5 ± 7.6 | 32.1 ± 6.8 | 0.000 | 0.001 |
TBIL (μmol/L) | 52.1 ± 131.0 | 104.7 ± 166.7 | 126.6 ± 158.3 | 0.001 | 0.002 |
GGT (IU/L) | 90.9 ± 85.6 | 138.6 ± 112.3 | 109 ± 93.3 | 0000 | 0.399 |
ALP (IU/L) | 186.7 ± 133.6 | 137.7 ± 87.7 | 171.9 ± 123.0 | 0.001 | 0.650 |
INR | 1.42 ± 0.81 | 1.88 ± 0.86 | 2.09 ± 1.04 | 0.000 | 0.000 |
Liver disease severity | |||||
Hepatitis (n, %) | 372 (45.8) | 7 (8.3) | 3 (15.8) | 0.000 | 0.009 |
CTP5-6 (n, %) | 189 (23.3) | 18 (21.4) | 3 (15.8) | 0.702 | 0.444 |
CTP7-9 (n, %) | 94 (11.6) | 14 (16.7) | 1 (5.3) | 0.173 | 0.713 |
CTP10-14 (n, %) | 120 (14.8) | 34 (40.5) | 7 (36.8) | 0.000 | 0.008 |
ACLF (n, %) | 37 (4.5) | 11 (13.1) | 5 (26.3) | 0.001 | 0.000 |
Mortality (n, %), | 33 (4.1) | 13 (15.5) | 7 (36.8) | 0.000 | 0.000 |
- Citation: Zhou HY, Yang X, Luo KZ, Jiang YF, Wang WL, Liang J, Li MM, Luo HY. Hepatitis B virus infection in patients with Wilson disease: A large retrospective study. World J Gastroenterol 2023; 29(32): 4900-4911
- URL: https://www.wjgnet.com/1007-9327/full/v29/i32/4900.htm
- DOI: https://dx.doi.org/10.3748/wjg.v29.i32.4900