Hepatitis B virus infection in patients with Wilson disease: A large retrospective study

Table 5 Factors associated with severe liver disease at the Wilson disease diagnosis

Factors (at diagnosis)	OR	95%CI	P value
Gender
Male	1
Female	1. 945	1.402-2.698	0.000
Age at diagnosis (yr)
Group 1 (0-10)	1
Group 2 (11-20)	1.766	1.145-2.723	0.010
Group 3 (21-30)	0.757	0.423-1.352	0.346
Group 4 (31-40)	1.178	0.646-2.148	0.594
Group 5 (41-65)	1.455	0.777-2.724	0.241
HBV infection
WD alone	1
WD with previous HBV	5.255	3.159-8.739	0.000
WD with current HBV	7.748	2.890-20.774	0.000

Severe liver disease is defined as patients with acute-on-chronic liver failure or a Child-Turcotte-Pugh score ≥ 10 at the Wilson disease diagnosis, HBV: Hepatitis B virus; WD: Wilson disease; OR: Odds ratio; CI: Confidence interval.