Different oncological features of colorectal cancer codon-specific KRAS mutations: Not codon 13 but codon 12 have prognostic value

Table 5 Cox regression analyses of recurrence-related factors in subgroups based on microsatellite instability status: Microsatellite stable/microsatellite instability-low versus microsatellite instability-high

	MSS/MSI-low (n = 2019)		MSI-high (n = 184)1
	HR (95%CI)	P value	HR (95%CI)	P value
Preoperative CEA ≥ 5.0 ng/mL	1.178 (0.839-1.653)	0.344	8.321 (1.387-49.920)	0.020
Rectal cancer (vs colon cancer)	1.238 (0.850-1.804)	0.266	-	-
Diverting stoma (+)	1.069 (0.707-1.617)	0.752	2.431 (0.139-42.442)	0.543
T3-4 stage (vs T0-2)	1.175 (1.038-1.202)	0.407	0.284 (0.020-4.032)	0.353
N1-2 stage (vs N0)	1.190 (0.879-1.610)	0.260	1.000 (0.151-6.643)	1.000
Tumor size (cm)	1.117 (1.038-1.202)	0.003	0.991 (0.713-1.379)	0.960
Lymphatic invasion	1.242 (0.909-1.698)	0.174	1.154 (0.149-8.923)	0.891
Vascular invasion	1.740 (1.282-2.363)	< 0.001	0.009 (0.000-29.277)	0.255
Perineural invasion	2.335 (1.663-3.279)	< 0.001	0.538 (0.049-5.909)	0.613
Metastatic LN	1.050 (1.020-1.081)	0.001	1.442 (0.865-2.402)	0.160
KRAS Codon 12 mutation	1.467 (1.077-1.998)	0.015	2.508 (0.406-15.510)	0.323
KRAS Codon 13 mutation	0.713 (0.390-1.301)	0.270	-	-
KRAS Codon 61 mutation	2.265 (0.915-5.605)	0.077	-	-

¹No values: Due to a small sample size, the hazard ratio and confidence interval were not pre.

MSI: Microsatellite instability; MSS: Microsatellite stable; HR: Hazard ratio; CI: Confidence interval; CEA: Carcinoembryonic antigen; MSI: Microsatellite instability; MSS: Microsatellite stable; LN: Lymph node.