Inherited CHEK2 p.H371Y mutation in solitary rectal ulcer syndrome among familial patients: A case report

Figure 2 Genetic background of the patients with solitary rectal ulcer syndrome patients in a mother-son relationship. A: Family tree of the familial patients with solitary rectal ulcer syndrome. Squares indicate male family members; circles indicate female family members; black indicate affected patients; white indicate healthy family members; slashes indicate deceased family members; arrow indicate the first diagnosed patient of the family; B: Schematic diagram of the CHEK2 protein; C: The differential expressions of CHEK2 and the downstream genes among the healthy control, and patients with inflammatory bowel diseases, rectal cancer, and solitary rectal ulcer syndrome, using the immunohistochemical staining; scale bars, 100 μm. IBD: Inflammatory bowel diseases; SRUS: Solitary rectal ulcer syndrome.