Fecal microbiota transplantation alleviates experimental colitis through the Toll-like receptor 4 signaling pathway

Figure 3 Toll-like receptor 4 knockout alleviated dextran sodium sulphate-induced inflammation in the colon. A: Scheme of the animal experimental design; B: The change in body weight of mice from days 0 to 7 during the disease course (knockout-dextran sodium sulphate [KO-DSS]: n = 8; wild type [WT]-DSS: n = 7); C: The bar chart represents the disease activity index (DAI) score on day 7; D: Representative colons (left) and statistical analysis (right) of colonic length; E: Representative hematoxylin and eosin staining of colon tissues (left), original magnification 100 ×, and histological scores (right). ^aP < 0.05, ^bP < 0.01, and ^cP < 0.001 were considered statistically significant. FMT: Fecal microbiota transplantation.