Antagonizing adipose tissue-derived exosome miR-103-hepatocyte phosphatase and tensin homolog pathway alleviates autophagy in non-alcoholic steatohepatitis: A trans-cellular crosstalk

Figure 4 MiR-103 transfers from adipocytes to hepatocytes. A: The fluorescence of liver tissue of mice injected with adipose tissue (AT)-exosomes or phosphate buffered saline; B: AT exosomes can be absorbed into alpha mouse liver 12 (AML-12) cells; C: Circulating exosomes can be absorbed into AML-12 cells; D: Transewell assay confirmed that miR-103 could be transferred from adipocytes to AML-12 cells. BAT: Brown adipose tissue; Exo: Exosomes; DIR: 1,1-dioctadecyl-3,3,3,3-tetramethylindotricarbocyaine iodide; Cir: Circulating; PBS: Phosphate buffered saline; DAPI: 4’,6-diamidino-2-phenylindole; AML-12: Alpha mouse liver 12.