Prevalence and risk factors of osteoporosis detected by dual-energy X-ray absorptiometry among Chinese patients with primary biliary cholangitis

Table 3 Multivariate analysis of risk factors for osteoporosis in overall and women patients with primary biliary cholangitis

Variables	Overall patients (n = 268)		Overall patients underwent liver biopsy (n = 163)		Women patients (n = 236)		Women patients underwent liver biopsy (n = 150)
	OR (95%CI)	P value	OR (95%CI)	P value	OR (95%CI)	P value	OR (95%CI)	P value
Age, per 10 years	1.80 (1.33-2.44)	< 0.001	1.95 (1.30-2.92)	0.001	1.63 (1.04-2.57)	0.035	2.02 (1.27-3.20)	0.003
Fatigue		NS		NS		NS		NS
Splenomegaly		NS		NS	2.62 (1.18-5.80)	0.018		NS
Gastroesophageal varices	2.11 (1.14-3.92)	0.018		NS		NS		NS
Ascites		NS		NS		NS		NS
BMI	0.85 (0.77-0.93)	< 0.001	0.87 (0.77-0.98)	0.023	0.83 (0.75-0.92)	< 0.001	0.85 (0.74-0.97)	0.014
Previous steroid use	4.19 (1.66-10.56)	0.002		NS	4.01 (1.42-11.31)	0.009	3.99 (1.24-12.87)	0.020
Mayo risk score	1.36 (1.08-1.71)	0.009		NS	1.61 (1.22-2.14)	0.001	1.64 (1.12-2.41)	0.011
ALT		NS		NS		NS		NS
Bilirubin		NS	1.20 (1.01-1.42)	0.044		NS		NS
Albumin		NS		NS		NS		NS
PTA		NS		NS		NS		NS
PLT		NS		NS		NS		NS
Postmenopausal					2.92 (1.02-8.38)	0.046		NS
Histological stage Ⅲ or Ⅳ			3.74 (1.60-8.77)	0.002			3.02 (1.13-8.06)	0.027

ALT: Alanine aminotransferase; BMI: Body mass index; CI: Confidence interval; NS: Not significant; OR: Odds ratio; PLT: Platelet count; PTA: Prothrombin activity.