γ-aminobutyric acid B2 receptor: A potential therapeutic target for cholangiocarcinoma in patients with diabetes mellitus

Figure 2 Antiproliferative and anti-clonogenic effects of γ-aminobutyric acid-B receptor agonist. A and B: Baclofen, a γ-aminobutyric acid-B receptor agonist, exerts significant antiproliferative effects on cholangiocarcinoma (CCA) cells in a dose-dependent (A) and time-dependent (B) manner; C and D: CCA cells cultured in high glucose condition (HG) are more sensitive to baclofen than those cultured in normal glucose (NG). Baclofen also shows anti-clonogenic effects on both NG and HG cells of CCA. Presented data are representatives of three biological replications of each triplicated experiment with the same trends of results. ^bP < 0.01, ^cP < 0.001. NG: Normal glucose; HG: High glucose.