Efficacy and dose response of Lactiplantibacillus plantarum in diarrhea-predominant irritable bowel syndrome

doi:10.3748/wjg.v29.i28.4451

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Jul 28, 2023 (publication date) through Dec 24, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Clinical Trials Study

World J Gastroenterol. Jul 28, 2023; 29(28): 4451-4465
Published online Jul 28, 2023. doi: 10.3748/wjg.v29.i28.4451

Table 1 Baseline demographics and clinical characteristics of the intention-to-treat population, n (%)

	Placebo 1B (n = 104)	L. plantarum 1B (n = 104)	L. plantarum 10B (n = 99)	P value
	mean (SD) or n (%)	mean (SD) or n (%)	mean (SD) or n (%)	P value
Age (yr)	39.50 (13.26)	38.66 (11.25)	40.46 (11.15)	0.5619¹
Female allocation	46 (44.23)	50 (48.08)	44 (44.44)	0.8232²
Height (m)	1.60 (0.07)	1.59 (0.08)	1.61 (0.07)	0.1775¹
Weight (kg)	63.57 (9.10)	63.09 (9.01)	63.25 (8.50)	0.9256¹
BMI (kg/m²)	24.83 (3.15)	25.01 (3.31)	24.46 (2.92)	0.4506¹
Systolic BP (mmHG)	119.68 (8.27)	119.76 (8.68)	118.88 (8.79)	0.7223¹
Diastolic BP (mmHG)	79.29 (5.06)	79.21 (6.30)	78.75 (4.62)	0.7429¹
Fasting glucose (mmol/L)	5.16 (0.66)	5.01 (0.65)	5.13 (0.62)	0.1961¹
IBS-SSS aggregate score	308.70 (70.91)	315.20 (62.79)	302.85 (61.06)	0.4090¹
APS-NRS score	7.14 (0.69)	7.14 (0.77)	7.17 (0.86)	0.9648¹
IBS-QoL aggregate score	36.19 (17.97)	37.83 (17.25)	37.54 (17.02)	0.7787¹
PSS score	22.06 (4.29)	22.42 (4.12)	21.93 (4.31)	0.6912¹

¹Between group comparison; one-way ANOVA.

²Between group comparison; Pearson chi-square test.

BMI: Body mass index; BP: Blood pressure; IBS-SSS: Irritable bowel syndrome-severity scoring system; APS-NRS: Abdominal pain severity-numeric rating scale; IBS-QoL: Irritable bowel syndrome-quality of life; PSS: Perceived stress scale; L. plantarum: Lactiplantibacillus plantarum.

Citation: Martoni CJ, Srivastava S, Damholt A, Leyer GJ. Efficacy and dose response of Lactiplantibacillus plantarum in diarrhea-predominant irritable bowel syndrome. World J Gastroenterol 2023; 29(28): 4451-4465
URL: https://www.wjgnet.com/1007-9327/full/v29/i28/4451.htm
DOI: https://dx.doi.org/10.3748/wjg.v29.i28.4451