18β-glycyrrhetinic acid promotes gastric cancer cell autophagy and inhibits proliferation by regulating miR-328-3p/signal transducer and activator of transcription 3

Figure 4 Signal transducer and activator of transcription 3 is targeted by miR-328-3p. A: TransmiR v2.0 database predicted miR-328-3p related proteins; B: STRING database predicted the relationship between Signal transducer and activator of transcription 3(STAT3) and autophagy-related proteins; C: Effect of miR-328-3p on the expression of STAT3 mRNA; D and E: Effect of miR-328-3p on the expression levels of STAT3 and phosphorylated STAT3; F: Schematic diagram of binding site between miR-328-3p and STAT3 3’ untranslated regions; G and H: STAT3 is the target gene of miR-328-3p. All analyses were repeated three times. The data is represented as the mean ± SD. ^aP < 0.05; ^bP < 0.01; ^cP < 0.001. NC: Negative control; Vector: The blank vector for lentivirus transfection; WT: Wild type; Mut: Mutant.