18β-glycyrrhetinic acid promotes gastric cancer cell autophagy and inhibits proliferation by regulating miR-328-3p/signal transducer and activator of transcription 3

Figure 1 Drug target miR-328-3p of 18β-glycyrrhetinic acid and its relationship with cell proliferation. A: Chemical structure of 18β-glycyrrhetinic acid (18β-GRA); B: Volcanic map; C: Heat map; D: Effect of 18β-GRA on expression of miR-328-3p in gastric cancer cells; E: Expression of miR-328-3p in gastric cancer cells transfected with lentivirus; F: Lentivirus transfected gastric cancer cells, cell status and transfection efficiency; G: Effect of overexpression of miR-328-3p on survival rate of AGS cells. All analyses were repeated three times. The data is represented as the mean ± SD. ^bP < 0.01; ^cP < 0.001. NC: Negative control; Vector: The blank vector for lentivirus transfection; GFP: Green fluorescent protein.