Stomach perforation-induced general occlusion/occlusion-like syndrome and stable gastric pentadecapeptide BPC 157 therapy effect

doi:10.3748/wjg.v29.i27.4289

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World Journal of Gastroenterology

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Basic Study

World J Gastroenterol. Jul 21, 2023; 29(27): 4289-4316
Published online Jul 21, 2023. doi: 10.3748/wjg.v29.i27.4289

Table 6 Lesions were assessed microscopically (cerebrum, cerebellum, hypothalamus, hippocampus), in rats at 15 min and 60 min following stomach perforation

Application of the 1 ml/rat through the perforated defect in the injured stomach at 5 min following perforation	Lesions scored microscopically cerebrum, cerebellum, hypothalamus, and hippocampus in rats at 15 min and 60 min following stomach perforation
	15 min	60 min
	Cerebrum (scored 0-8, min/med/max); percentage of karyopycnotic cells (%), mean ± SD
Control	2/2/2; 30 ± 5	2/2/2, 35 ± 5
BPC 157 10 μg/kg	0/1/1^a, 5 ± 5^a	0/1/1^a, 5 ± 5^a
BPC 157 10 ng/kg	0/1/1^a, 5 ± 5^a	0/1/1^a, 5 ± 5^a
	Neuronal damage in the karyopyknotic areas, %, mean ± SD (10 HPF, 400 ×)
Control	39 ± 5	42 ± 4
BPC 157 10 μg/kg	2 ± 2^a	3 ± 2^a
BPC 157 10 ng/kg	2 ± 2^a	2 ± 2^a
	Hemorrhage (% of total area), mean ± SD
Control	30 ± 2	25 ± 2
BPC 157 10 μg/kg	5 ± 2^a	5 ± 2^a
BPC 157 10 ng/kg
	Edema (scored 0-3, min/med/max)
Control	37683	37683
BPC 157 10 μg/kg	1/1/1^a	1/1/1^a
BPC 157 10 ng/kg	1/1/1^a	1/1/1^a
	Cerebellum (scored 0-8, min/med/max); percentage of karyopycnotic cells (%), mean ± SD
Control	1/2/2, 13 ± 5	1/1/1, 15 ± 5
BPC 157 10 μg/kg	0/0/1^a, 5 ± 5^a	0/0/1^a, 5 ± 5^a
BPC 157 10 ng/kg	0/0/1^a, 5 ± 5^a	0/0/1^a, 5 ± 5^a
	Neuronal damage in the karyopyknotic areas (%), mean ± SD (10 HPF, 400 ×)
Control	27 ± 4	23 ± 5
BPC 157 10 μg/kg	0 ± 0^a	0 ± 0^a
BPC 157 10 ng/kg	0 ± 0^a	0 ± 0^a
	Hemorrhage (% of total area), mean ± SD
Control	0 ± 0	0 ± 0
BPC 157 10 μg/kg	0 ± 0	0 ± 0
BPC 157 10 ng/kg	0 ± 0	0 ± 0
	Edema (scored 0-3, min/med/max)
Control	37683	37318
BPC 157 10 μg/kg	0/0/1^a	0/0/1^a
BPC 157 10 ng/kg	0/0/1^a	0/0/1^a
	Hippocampus (scored 0-8, min/med/max); percentage of karyopycnotic cells (%), mean ± SD
Control	37289	36924
Control	25 ± 3	28 ± 2
BPC 157 10 μg/kg	0/0/0^a, 0 ± 0^a	0/0/0^a, 0 ± 0^a
BPC 157 10 ng/kg	0/0/0^a, 0 ± 0^a	0/0/0^a, 0 ± 0^a
	Neuronal damage in the karyopyknotic areas (%), mean ± SD (10 HPF, 400 ×)
Control	23 ± 2	24 ± 3
BPC 157 10 μg/kg	0 ± 0^a	0 ± 0^a
BPC 157 10 ng/kg	0 ± 0^a	0 ± 0^a
	Hemorrhage (% of total area), mean ± SD
Control	0 ± 0	0 ± 0
BPC 157 10 μg/kg	0 ± 0	0 ± 0
BPC 157 10 ng/kg	0 ± 0	0 ± 0
	Edema (scored 0-3, min/med/max)
Control	37683	37318
BPC 157 10 μg/kg	0/0/0^a	0/0/0^a
BPC 157 10 ng/kg	0/0/0^a	0/0/0^a
	Hypothalamus (scored 0-8, min/med/max); percentage of karyopycnotic cells (%), mean ± SD
Control	2/2/2, 31 ± 3	1/1/1, 29 ± 4
BPC 157 10 μg/kg	0/0/1^a, 5 ± 5^a	0/0/1^a, 5 ± 5^a
BPC 157 10 ng/kg	0/0/1^a, 5 ± 5^a	0/0/1^a, 5 ± 5^a
	Neuronal damage in the karyopyknotic areas (%), mean ± SD (10 HPF, 400 ×)
Control	24 ± 3	28 ± 5
BPC 157 10 μg/kg	5 ± 2^a	6 ± 3^a
BPC 157 10 ng/kg	5 ± 2^a	6 ± 3^a
	Hemorrhage (% of total area), mean ± SD
Control	0 ± 0	0 ± 0
BPC 157 10 μg/kg	0 ± 0	0 ± 0
BPC 157 10 ng/kg	0 ± 0	0 ± 0
	Edema (scored 0-3, min/med/max)
Control	37683	37318
BPC 157 10 μg/kg	0/1/1^a	0/1/1^a
BPC 157 10 ng/kg	0/1/1^a	0/1/1^a

^aP < 0.05, at least vs control.

Lesions were assessed microscopically (cerebrum, cerebellum, hypothalamus, and hippocampus), in rats at 15 min and 60 min following stomach perforation. Saline (5 mL/kg, control) or BPC 157 (10 μg/kg and 10 ng/kg) were given at 5 min thereafter.

Citation: Kalogjera L, Krezic I, Smoday IM, Vranes H, Zizek H, Yago H, Oroz K, Vukovic V, Kavelj I, Novosel L, Zubcic S, Barisic I, Beketic Oreskovic L, Strbe S, Sever M, Sjekavica I, Skrtic A, Boban Blagaic A, Seiwerth S, Sikiric P. Stomach perforation-induced general occlusion/occlusion-like syndrome and stable gastric pentadecapeptide BPC 157 therapy effect. World J Gastroenterol 2023; 29(27): 4289-4316
URL: https://www.wjgnet.com/1007-9327/full/v29/i27/4289.htm
DOI: https://dx.doi.org/10.3748/wjg.v29.i27.4289