Stomach perforation-induced general occlusion/occlusion-like syndrome and stable gastric pentadecapeptide BPC 157 therapy effect

doi:10.3748/wjg.v29.i27.4289

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World Journal of Gastroenterology

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World J Gastroenterol. Jul 21, 2023; 29(27): 4289-4316
Published online Jul 21, 2023. doi: 10.3748/wjg.v29.i27.4289

Table 5 Lesions scored microscopically (heart, lung, liver, kidney, stomach), or macroscopically (stomach, in rats at 15 min and 60 min following stomach perforation

Application of the 1 mL/rat through the perforated defect in the injured stomach at 5 min following perforation	Lesions scored microscopically (heart, lung, liver, kidney, stomach, small and large intestine), or macroscopically (stomach), in rats at 15 min and 60 min following stomach perforation
	15 min	60 min
	Heart (scored 0-3, min/med/max)
Control	3/3/3	3/3/3
BPC 157 10 μg/kg	0/0/0^a	0/0/0^a
BPC 157 10 ng/kg	0/0/0^a	0/0/0^a
	Lung (scored 0-3, min/med/max)
Control	3/3/3	3/3/3
BPC 157 10 μg/kg	1/1/1^a	1/1/1^a
BPC 157 10 ng/kg	1/1/1^a	1/1/1^a
	Liver (scored 0-3, min/med/max)
Control	3/3/3	3/3/3
BPC 157 10 μg/kg	0/0/0^a	0/0/0^a
BPC 157 10 ng/kg	0/0/0^a	0/0/0^a
	Kidney (scored 0-3, min/med/max)
Control	3/3/3	3/3/3
BPC 157 10 μg/kg	0/0/0^a	0/0/0^a
BPC 157 10 ng/kg	0/0/0^a	0/0/0^a
	Stomach (scored 0-15, min/med/max)
Control	5/5/5	4/5/5
BPC 157 10 μg/kg	1/1/1^a	1/1/1^a
BPC 157 10 ng/kg	1/1/1^a	1/1/1^a

^aP < 0.05, at least vs control.

Lesions scored microscopically (heart, lung, liver, kidney, and stomach), or macroscopically (stomach, in rats at 15 min and 60 min following stomach perforation. Saline (5 mL/kg, control) or BPC 157 (10 μg/kg and 10 ng/kg) were given at 5 min thereafter.

Citation: Kalogjera L, Krezic I, Smoday IM, Vranes H, Zizek H, Yago H, Oroz K, Vukovic V, Kavelj I, Novosel L, Zubcic S, Barisic I, Beketic Oreskovic L, Strbe S, Sever M, Sjekavica I, Skrtic A, Boban Blagaic A, Seiwerth S, Sikiric P. Stomach perforation-induced general occlusion/occlusion-like syndrome and stable gastric pentadecapeptide BPC 157 therapy effect. World J Gastroenterol 2023; 29(27): 4289-4316
URL: https://www.wjgnet.com/1007-9327/full/v29/i27/4289.htm
DOI: https://dx.doi.org/10.3748/wjg.v29.i27.4289