Stomach perforation-induced general occlusion/occlusion-like syndrome and stable gastric pentadecapeptide BPC 157 therapy effect

Table 4 ECG changes, PQ interval, QTc interval, msec, heart frequency, beats/min, in rats at 15 min and 60 min following stomach perforation

Application of the 1 mL/rat through the perforated defect in the injured stomach at 5 min following perforation	ECG changes in rats at 15 min and 60 min following stomach perforation
	15 min	60 min
	PQ interval, msec mean ± SD
Control	64 ± 5	67 ± 6
BPC 157 10 μg/kg	50 ± 5a	50 ± 5a
BPC 157 10 ng/kg	50 ± 5a	50 ± 5a
	QTc interval, msec, mean ± SD
Control	312 ± 10	347 ± 10
BPC 157 10 μg/kg	180 ± 10a	188 ± 10a
BPC 157 10 ng/kg	185 ± 10a	183 ± 10a
	Heart frequency, beats/min, mean ± SD
Control	530 ± 30	550 ± 30
BPC 157 10 μg/kg	375 ± 10 a	360 ± 10a
BPC 157 10 ng/kg	385 ± 10 a	365 ± 10a

^aP < 0.05, at least vs control.

ECG changes, PQ interval, QTc interval, msec, heart frequency, beats/min, in rats at 15 min and 60 min following stomach perforation. Saline (5 mL/kg, control) or BPC 157 (10 μg/kg and 10 ng/kg) were given at 5 min thereafter.