Stomach perforation-induced general occlusion/occlusion-like syndrome and stable gastric pentadecapeptide BPC 157 therapy effect

Table 3 Relative volume of the brain, inferior caval vein, and superior mesenteric vein, and relative volume of the heart, azygos vein, in rats at 15 min and 60 min following stomach perforation

0 min	5 min	15 min	60 min
Relative volume (healthy/perforation, %) of the brain, heart, azygos vein, inferior caval vein, superior mesenteric vein, and abdominal aorta in rats immediately after perforation	Application of the 1 mL/rat through the perforated defect in the injured stomach at 5 min following perforation	Relative volume (healthy/perforation, healthy/perforation + therapy, %) of the brain, inferior caval vein, and superior mesenteric vein, and relative volume (control/treated, %) of the heart, azygos vein, in rats at 15 min and 60 min following stomach perforation
Relative volume (healthy/perforation) (%) of the brain, mean ± SD	Medication	Relative volume (healthy/perforation + therapy, %) of the brain, mean ± SD
116 ± 3a	Saline 5 mL/kg (control)	124 ± 2a,b	124 ± 2a,b
120 ± 2a	BPC 157 10 μg/kg	100 ± 1b,c	99 ± 2b,c
121 ± 2a	BPC 157 10 ng/kg	101 ± 3b,c	100 ± 1b,c
-	Relative volume (control/treated, %) of the heart, mean ± SD
	BPC 157 10 μg/kg	137 ± 4c	141 ± 5c
	BPC 157 10 ng/kg	136 ± 3c	138 ± 4c
	Relative volume (control/treated, %) of the azygos vein, mean ± SD
	BPC 157 10 μg/kg	66 ± 6c	58 ± 7c
	BPC 157 10 ng/kg	64 ± 4c	54 ± 8c
	Relative volume (healthy/perforation + therapy, %) of the inferior caval vein, mean ± SD
130 ± 3a	Saline 5 mL/kg (control)	164 ± 8a,b	174 ± 9a,b
128 ± 4a	BPC 157 10 μg/kg	98 ± 2b,c	100 ± 2b,c
126 ± 4a	BPC 157 10 ng/kg	100 ± 3b,c	99 ± 1b,c
	Relative volume (healthy/perforation + therapy, %) of the superior mesenteric vein, mean ± SD
180 ± 5a	Saline 5 mL/kg (control)	204 ± 8a,b	212 ± 9a,b
188 ± 9a	BPC 157 10 μg/kg	96 ± 6b,c	99 ± 7b,c
186 ± 8a	BPC 157 10 ng/kg	98 ± 6b,c	101 ± 1b,c

^aP < 0.05, at least vs healthy.

^bP < 0.05, at least vs immediately after perforation.

^cP < 0.05, at least vs corresponding control at the time of the assessment.

Relative volume (healthy/perforation, healthy/perforation + therapy, %) of the brain, inferior caval vein, and superior mesenteric vein, and relative volume (control/treated, %) of the heart, azygos vein, in rats at 15 min and 60 min following stomach perforation. Saline (5 mL/kg) (control) or BPC 157 (10 μg/kg and 10 ng/kg) were given at 5 min after perforation.