Stomach perforation-induced general occlusion/occlusion-like syndrome and stable gastric pentadecapeptide BPC 157 therapy effect

Table 1 Blood pressures and thrombosis in rats at 15 min and 60 min following stomach perforation

Application of the 1 mL/rat through the perforated defect in the injured stomach at 5 min following perforation	Blood pressures and thrombosis in rats at 15 min and 60 min following stomach perforation
	15 min	60 min
Superior sagittal sinus pressure, mmHg, mean ± SD
Control	9 ± 1	8 ± 1
BPC 157 10 μg/kg	-3 ± 1a	-1 ± 1a
BPC 157 10 ng/kg	-1 ± 1a	-2 ± 1a
Portal pressure, mmHg, mean ± SD
Control	16 ± 2	17 ± 1
BPC 157 10 μg/kg	9 ± 1a	9 ± 1a
BPC 157 10 ng/kg	9 ± 1a	8 ± 1a
Caval pressure, mmHg, mean ± SD
Control	15 ± 1	15 ± 1
BPC 157 10 μg/kg	8 ± 1	9 ± 1a
BPC 157 10 ng/kg	7 ± 1	9 ± 1a
Aortal pressure, mmHg, mean ± SD
Control	42 ± 5	45 ± 7
BPC 157 10 μg/kg	75 ± 4a	72 ± 5a
BPC 157 10 ng/kg	80 ± 5a	78 ± 7a
Superior sagittal sinus, thrombus mass, g, mean ± SD
Control	0.0012 ± 0.0005	0.0022 ± 0.0009
BPC 157 10 μg/kg	0 ± 0a	0 ± 0a
BPC 157 10 ng/kg	0 ± 0a	0 ± 0a
Portal vein, thrombus mass, g, mean ± SD
Control	0.0034 ± 0.0006	0.0056 ± 0.0008
BPC 157 10 μg/kg	0.0010 ± 0.0005a	0.0020 ± 0.0005a
BPC 157 10 ng/kg	0.0010 ± 0.0007a	0.0018 ± 0.0006a
Inferior caval vein, thrombus mass, g, mean ± SD
Control	0.0039 ± 0.0007	0.0061 ± 0.0008
BPC 157 10 μg/kg	0.0002 ± 0.0001a	0.0003 ± 0.0001a
BPC 157 10 ng/kg	0.0008 ± 0.0001a	0.0005 ± 0.0002a
Abdominal aorta, thrombus mass, g, mean ± SD
Control	0.0044 ± 0.0007	0.0063 ± 0.0009
BPC 157 10 μg/kg	0 ± 0a	0 ± 0a
BPC 157 10 ng/kg	0 ± 0a	0 ± 0a

^aP < 0.05, at least vs control.

Blood pressures (intracranial (superior sagittal sinus), portal and caval hypertension and aortal hypotension, mmHg), and thrombosis (thrombus mass, g) in rats at 15 min and 60 min following perforation of the stomach. Saline (5 mL/kg) (control) or BPC 157 (10 μg/kg and 10 ng/kg) were given at 5 min thereafter.