Sarcopenia in cirrhosis: Prospects for therapy targeted to gut microbiota

doi:10.3748/wjg.v29.i27.4236

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jul 21, 2023; 29(27): 4236-4251
Published online Jul 21, 2023. doi: 10.3748/wjg.v29.i27.4236

Table 5 Effects of interventions targeting the gut microbiota on pathogenic factors in the gut-muscle axis in cirrhosis

Intervention	SIBO	Gut dysbiosis	Hyperammonemia	Bacterial translocation	Systemic inflammation
Rifaximin	+	+	+	+	CR
Prebiotic disaccharides	ND	+	+	+	+
Probiotics	+	+	+	+	CR
Fecal transplantation	ND	+	ND	ND	ND

+: A positive effect of this drug on this disorder has been reported; SIBO: Small intestinal bacterial overgrowth; CR: Conflicting results, ND: No data.

Citation: Maslennikov R, Alieva A, Poluektova E, Zharikov Y, Suslov A, Letyagina Y, Vasileva E, Levshina A, Kozlov E, Ivashkin V. Sarcopenia in cirrhosis: Prospects for therapy targeted to gut microbiota. World J Gastroenterol 2023; 29(27): 4236-4251
URL: https://www.wjgnet.com/1007-9327/full/v29/i27/4236.htm
DOI: https://dx.doi.org/10.3748/wjg.v29.i27.4236