Raf kinase inhibitor protein combined with phosphorylated extracellular signal-regulated kinase offers valuable prognosis in gastrointestinal stromal tumor

Table 1 Relationship between proteins expression and clinical and pathological characteristics of gastrointestinal stromal tumors

Characteristic	n	RKIP			P-ERK			P-MEK
		Negative	Positive	P valuea	Negative	Positive	P valuea	Negative	Positive	P valuea
Sex
Male	36	16	20	0.652	16	20	0.716	22	14	0.365
Female	30	15	15		12	18		15	15
Age in yr
> 56	33	17	16	0.459	13	20	0.618	15	18	0.083
≤ 56	33	14	19		15	18		22	11
Tumor location
Stomach	37	20	17	0.585	16	21	0.902	21	16	0.224
Duodenum	12	4	8		4	8		4	8
Jejunoileum	15	6	9		7	8		11	4
Colon	2	1	1		1	1		1	1
Tumor size in cm
< 2	12	1	11	< 0.001	8	4	0.009	7	5	0.353
2-5	20	5	15		12	8		14	6
6-10	19	14	5		6	13		10	9
> 10	15	11	4		2	13		6	9
NIH risk grade
Very low	10	2	8	< 0.001	7	3	0.004	7	3	0.319
Low	20	3	17		13	7		11	9
Moderate	11	8	3		3	8		8	3
High	25	18	7		5	20		11	14
Mitotic figures as /50 HPFs
0	11	3	8	0.074	5	6	0.015	5	6	0.604
1-4	37	15	22		21	16		22	15
5-10	7	5	2		1	6		5	2
> 10	11	8	3		1	10		5	6
Mucosal invasion
Yes	34	21	13	0.013	10	24	0.027	18	16	0.599
No	32	10	22		18	14		19	13

^aRaf kinase inhibitory protein (RKIP)-positive percentage were compared using the χ² test, P < 0.05 were considered statistically significant.

HPFs: High-power fields; NIH: National Institutes of Health; P-ERK: Phosphorylated extracellular-signal regulated kinase; P-MEK: Phosphorylated mitogen-activated protein kinase\ERK kinase.