Impact of COVID-19 in individuals with and without pre-existent digestive disorders with a particular focus on elderly patients

Table 3 Summary of studies on the relationship between liver disease and coronavirus disease 2019 in elderly patients

Ref.	Outcome considered	Results
Khateri et al[108]	Incidence of acute liver injury in patients affected by COVID-19	Acute liver injury has no relationship with age
Metawea et al[110]	Mortality of patients with hepatocellular carcinoma infected with COVID-19	Age is associated with poorer outcomes and higher mortality
Ji et al[111]	Severe COVID-19 in patients affected by NAFLD	Associated in patients older than 60 yr
Zhou et al[112]	Severe COVID-19 in patients affected by NAFLD	Associated in patients younger than 60 yr
Hartl et al[113]	Liver-related death due to COVID-19 between different age groups	More frequent in the 40-69 years old group than in the over 70 years old group (6.5% vs 2.2%)
Ioannou et al[115]	Predictors of mortality among patients with cirrhosis and SARS-CoV-2 infection	Advanced age was one of the main risk factors for mortality among patients with cirrhosis and SARS-CoV-2 infection
Brozat et al[116]	The case fatality rate in patients with cirrhosis and SARS-CoV-2 infection	The case fatality rate in cirrhotic patients and SARS-CoV-2 infection aged 65 yr and older was nearly three times that in patients younger than 65 yr (43.6% vs 16.1%)

SARS-CoV-2: Severe acute respiratory syndrome coronavirus 2; COVID-19: Coronavirus disease 2019; NAFLD: Non-alcoholic fatty liver disease.