Insulin resistance and adipose tissue interactions as the cornerstone of metabolic (dysfunction)-associated fatty liver disease pathogenesis

Figure 1 Effect of insulin resistance on adipose tissue lipolysis. Under normal circumstances, insulin inhibits lipolysis in adipose tissue by inducing the hormone sensitive lipase, thus decreasing the release of excessive free fatty acids (FFAs) into the serum. However, in an insulin resistance state, inhibition of lipolysis is blocked, increasing serum FFAs, which eventually increase the influx of lipids into the liver. All the figures were created using BioRender. AT: Adipose tissue; IR: Insulin resistance.