Comparison and development of machine learning for thalidomide-induced peripheral neuropathy prediction of refractory Crohn’s disease in Chinese population

Figure 4 Examination of consequences between the top four single nucleotide polymorphisms and gene expression in nerve tibial tissue. Patients with interleukin (IL)-12 rs1353248_TT (chr3_159905770, P = 8.52 × 10^-4), brain-derived neurotrophic factor (BDNF) rs6265_CT (chr11_27658369, P = 1.07 × 10^-4) BDNF rs2030324_AG (chr11_27705368, P = 9.2 × 10^-11), and BDNF rs11030104_AG (chr11_27662970, P = 2.76 × 10^-5). A: IL-12; B-D: BDNF. The expression levels of the BDNF gene were reduced in rs6265CT and rs11030104AG. Additionally, the expression levels of the IL-12 gene were significantly decreased in the rs1353248TT. BDNF: Brain-derived neurotrophic factor; IL: Interleukin.