Vascular endothelial growth factor protein and gene delivery by novel nanomaterials for promoting liver regeneration after partial hepatectomy

Figure 1 Schematic Illustration of liver after partial hepatectomy. After partial hepatectomy, hepatocytes begin to proliferate and release vascular endothelial growth factor, which promotes the proliferation of bone marrow-derived progenitor cells (BM SPCs) and reconstruction of hepatic sinusoids. BM SPCs secrete hepatocyte growth factor, which provides positive feedback and promotes hepatocytes proliferation. This figure was created with BioRender (BioRender.com). VEGF: Vascular endothelial growth factor; HGF: Hepatocyte growth factor; BM SPCs: Bone marrow-derived progenitor cells.