Comparison and development of machine learning for thalidomide-induced peripheral neuropathy prediction of refractory Crohn’s disease in Chinese population

Table 2 Univariate analyses of factors associated with thalidomide-induced peripheral neuropathy

SNP	Gene	Minor allele	Main allele	OR	95%CI	P value
rs1353248	IL-12	T	C	8.983	2.497-30.90	0.0004
rs6265	BDNF	T	C	3.150	1.546-6.073	0.001
rs2030324	BDNF	G	A	3.164	1.561-6.434	0.001
rs11030104	BDNF	G	A	3.091	1.525-5.960	0.001
rs10991419	ABCA1	T	C	3.833	1.521-8.926	0.002
rs7795841	ABCB1	G	T	4.333	1.371-13.39	0.014
rs2575876	ABCA1	A	G	2.559	1.306-5.209	0.007
rs3918249	MMP9	T	C	3.800	1.208-10.50	0.016
rs7795846	ABCB1	A	G	3.690	1.155-10.25	0.020
rs62447181	IKZF1	A	G	2.933	0.763-9.514	0.096
rs11030100	BDNF	G	T	2.205	1.074-4.430	0.030
rs2777795	ABCA1	A	G	1.830	0.793-4.114	0.09
rs12718731	IKZF1	G	A	2.471	0.686-8.328	0.1
rs34165419	ABCA1	T	C	2.564	0.664-10.41	0.1

CI: Confidence interval; OR: Odds ratio; TiPN: Thalidomide-induced peripheral neuropathy; BDNF: Brain-derived neurotrophic factor; IL: Interleukin; SNP: Single nucleotide polymorphisms.