Prediction of lymph node metastasis in early gastric signet-ring cell carcinoma: A real-world retrospective cohort study

Table 1 Clinical characteristics in patients with early gastric cancer

	SRCC	NSRC	P value
	n = 249, n (%)	n = 1673, n (%)
Age (yr)	53.14 ± 10.03	57.01 ± 11.78	< 0.001
≤ 65	161 (64.66)	634 (37.90)
> 65	88 (35.34)	1039 (62.10)
Gender			< 0.001
Male	133 (53.41)	1238 (74.00)
Female	116 (46.59)	435 (26.00)
Location			< 0.001
Cardia	11 (4.42)	235 (14.05)
Fundus	5 (2.01)	143 (8.55)
Body	43 (17.27)	296 (17.69)
Antrum	129 (51.81)	641 (38.31)
Angle	61 (24.50)	358 (21.40)
Macroscopic type			0.105
Protruded (0-I)	3 (1.20)	27 (1.61)
Elevated (0-IIa)	11 (4.42)	128 (7.65)
Flat (0-IIb)	52 (20.88)	353 (21.10)
Depressed (0-IIc)	178 (71.49)	1076 (64.32)
Excavated (0-III)	5 (2.01)	89 (5.32)
Tumor size (cm)	2.14 ± 1.43	1.89 ± 1.22	0.001
≤ 2	139 (55.82)	1124 (67.18)
> 2	110 (44.18)	549 (32.82)
Ulceration			0.027
UL (-)	175 (70.28)	1046 (62.52)
UL (+)	74 (29.72)	627 (37.48)
Depth of invasion			0.001
M	149 (59.84)	808 (48.30)
SM	100 (40.16)	865 (51.70)
LVI			1
Absence	231 (92.77)	1555 (92.95)
Presence	18 (7.23)	118 (7.05)
Perineural invasion			0.041
Absence	242 (97.19)	1658 (99.10)
Presence	7 (2.81)	15 (0.90)
LNM			< 0.001
Absence	187 (75.10)	1457 (87.09)
Presence	62 (24.90)	216 (12.91)

SRCC: Signet-ring cell carcinoma; NSRC: Non-signet ring cell carcinoma; LVI: Lymphovascular invasion; LNM: Lymph node metastasis; M: Mucosal; SM: Submucosal; UL (-): Ulcer or ulcer scar is absent; UL (+): Ulcer or ulcer scar is present.