Mechanism of ELL-associated factor 2 and vasohibin 1 regulating invasion, migration, and angiogenesis in colorectal cancer

Table 3 Univariate and multivariate survival analysis of overall survival for colorectal cancer by Cox regression.

Variables	Univariate analysis			Multivariate analysis
	HR	95%CI	P value	HR	95%CI	P value
Age (yr) (≥ 61/< 61)	1.703	0.969-2.991	0.064	1.413	0.764-2.613	0.270
Gender (female/male)	0.962	0.561-1.651	0.890
Tumor site (colon/rectum)	1.410	0.798-2.492	0.237	1.211	0.638-2.298	0.558
Size of the tumor, cm (> 4/≤ 4)	0.777	0.446-1.356	0.375
Histological type (mucinous/non-mucinous)	1.218	0.612-2.424	0.574
Degree of differentiation (poor/mucinous, well/moderate)	0.917	0.523-1.608	0.761
Angiolymphatic and/or perineural invasion (present/absent)	0.209	0.107-0.408	< 0.001	0.255	0.072-0.898	0.033
Tumor stage (III-IV/I-II)	0.240	0.128-0.450	< 0.001	1.455	0.339-6.256	0.614
Tumor invasion depth (T4/T2-T3)	0.353	0.202-0.614	< 0.001	0.547	0.225-1.331	0.184
Lymph node status (N1-N2/N0)	0.288	0.155-0.532	< 0.001	2.150	0.511-9.038	0.296
Distant metastasis (present/absent)	0.161	0.091-0.284	< 0.001	0.200	0.090-0.444	< 0.001
EAF2 (low/high)	3.244	1.170-8.999	0.024	2.049	0.698-6.014	0.191
VASH1 (high/low)	0.518	0.266-1.007	0.052	0.785	0.389-1.584	0.499
CEA (high/low)	1.590	0.906-2.790	0.106	2.506	1.336-4.702	0.004
CA19-9 (high/low)	0.817	0.466-1.433	0.481
P53 (high/low)	0.558	0.313-0.994	0.048	0.545	0.299-0.995	0.048
CDX2 (high/low)	0.705	0.332-1.495	0.362

HR: Hazard ratio; CI: Confidence interval; EAF2: ELL protein-associated factor 2; CEA: Carcinoembryonic antigen; CA19-9: Carbohydrate antigen 19-9.