Mechanism of ELL-associated factor 2 and vasohibin 1 regulating invasion, migration, and angiogenesis in colorectal cancer

Table 2 Baseline characteristics of patients with advanced colorectal cancer and the correlation with immunohistochemical expression of ELL-associated factor 2 and vasohibin 1

Clinicopathologic characteristics	Cases, n (%)	EAF2		P value	VASH1		P value
		Low (n = 100)	High (n = 20)		Low (n = 36)	High (n = 84)
Age (yr)				0.569			0.248
< 61 (median)	44.17	43	10		13	40
≥ 61	55.83	57	10		23	44
Gender				0.935			0.843
Male	54.17	54	11		20	45
Female	45.83	46	9		16	39
Tumor site				0.657			0.515
Colon	29.17	30	5		9	26
Rectum	70.83	70	15		27	58
Size of the tumor, cm				0.250			0.689
≤ 4	41.67	44	6		16	34
> 4	58.33	56	14		20	50
Histological type				0.695			0.566
Mucinous	21.67	21	5		9	17
Non-mucinous	78.33	79	15		27	67
Degree of differentiation				0.013			0.042
Well/moderately differentiated	64.17	69	8		28	49
Poor/mucinous differentiated	35.83	31	12		8	35
Angiolymphatic and/or perineural invasion				0.049			0.006
Absent	45.00	41	13		23	31
Present	55.00	59	7		13	53
TNM				0.034			0.068
I-II	48.33	44	14		22	36
III-IV	51.67	56	6		14	48
Tumor invasion depth				0.219			0.084
T2-T3	57.50	55	14		25	44
T4	42.50	45	6		11	40
Lymph node status				0.073			0.095
N0	46.67	43	13		21	35
N1-N2	53.33	57	7		15	49
Distant metastasis				0.007			0.037
Absent	70.00	65	19		30	54
Present	30.00	35	1		6	30
CEA				0.021			0.874
Normal	56.67	52	16		20	48
High	43.33	48	4		16	36
CA19-9				0.321			0.809
Normal	40.00	38	10		15	33
High	60.00	62	10		21	51
P53				0.219			0.905
Normal	42.50	40	11		15	36
High	57.50	60	9		21	48
CDX2				0.224			0.921
Normal	20.00	18	6		7	17
High	80.00	82	14		29	67

EAF2: ELL protein-associated factor 2; TNM: Tumor-node-metastasis; CEA: Carcinoembryonic antigen; CA19-9: Carbohydrate antigen 19-9; VASH1: Vasohibin 1.