18β-glycyrrhetinic acid inhibits proliferation of gastric cancer cells through regulating the miR-345-5p/TGM2 signaling pathway

Figure 8 MicroRNAs transcriptomic analysis and dual-luciferase reporter assay. A: MicroRNAs (miRNAs) transcriptomics analysis of differentially expressed miRNAs; B: Effect of 18β-glycyrrhetinic acid (18β-GRA) with different concentrations of miR-345-5p expression level in AGS cells; C: Effect of 18β-GRA with different concentrations of miR-345-5p expression level in HGC-27 cells; D: Complementary binding sites of miR-345-5p and TGM2; E: Elevated expression of miR-345-5p suppressed the luciferase value of the TGM2-wild-type reporter but not that under the mutant reporter. All data are from three independent samples. The data is represented as the mean ± SD. ^aP < 0.05, ^bP < 0.01, ^cP < 0.001. 18β-GRA: 18β-glycyrrhetinic acid; WUT: Mutant; WT: Wild type; NC: Empty lentiviral vector.