High expression of the circadian clock gene NPAS2 is associated with progression and poor prognosis of gastric cancer: A single-center study

Table 2 Univariate and multivariate Cox analysis of clinicopathological factors associated with the overall survival of gastric cancers

Characteristics	Univariate analysis		Multivariate analysis
	Hazard ratio (95%CI)	P value	Hazard ratio (95%CI)	P value
Age
< 60	1
≥ 60	1.33 (0.82-2.17)	0.25
Gender
Female	1
Male	1.13 (0.63-2.05)	0.679
TNM stage
I-II	1
III-IV	7.07 (3.47-14.41)	< 0.001	3.61 (1.37-9.49)	0.009
pT stage
T1-T2	1
T3-T4	1.87 (0.81-4.35)	0.143
pN stage
N0	1
N1-N3	1.72 (1.38-2.15)	< 0.001	1.66 (0.68-4.07)	0.265
Metastasis
M0	1
M1	4.85 (2.24-10.46)	< 0.001	3.07 (1.33-7.1)	0.009
Tumor size
< 5	1
≥ 5	1.63 (0.97-2.72)	0.063
Tumor location
Antrum	1
Body	0.92 (0.53-1.60)	0.76
Cardia	1.13 (0.58-2.23)	0.72
Venous invasion
Negative	1
Positive	5.01 (1.57-15.98)	0.007	1.69 (0.49-5.84)	0.409
Neural invasion
Negative	1
Positive	1.73 (1.03-2.9)	0.037	1.71 (0.98-3)	0.06
Lymphatic invasion
Negative	1
Positive	3.53 (1.88-6.64)	< 0.001	0.39 (0.09-1.77)	0.225
Positive lymph node
Negative
Positive	3.35 (1.82-6.18)	< 0.001	2.23 (0.58-8.49)	0.241
Differentiated degree
Moderately and highly	1
Poorly	0.62 (0.29-1.30)	0.203
Lauren’s Classification
Diffuse type	1
Intestinal type	0.97 (0.57-1.64)	0.908
	0.97 (0.57-1.64)
NPAS2 expression
Low	1
High	5.13 (2.6-10.13)	< 0.001	2.43 (1.15-5.13)	0.020

pT stage: Pathological assessment of primary tumor; pN stage: Pathological assessment of regional lymph nodes; TNM: Tumor-node-metastasis.