High expression of the circadian clock gene NPAS2 is associated with progression and poor prognosis of gastric cancer: A single-center study

Table 1 Correlation between clinicopathological characteristic and NPAS2 in gastric cancer

Characteristic	Low expression of NPAS2	High expression of NPAS2	P value
Number	35	66
Age, n (%)			0.599
< 60	21 (60.0)	36 (54.5)
≥ 60	14 (40.0)	30 (45.5)
Sex, n (%)			0.626
Female	7 (20.0)	16 (24.2)
Male	28 (80.0)	51 (75.8)
TNM stage, n (%)			0.001
I-II	25 (71.4)	11 (16.7)
III-IV	10 (28.6)	55 (83.3)
pT stage, n (%)			0.351
T1-T2	6 (17.1)	29 (82.9)
T3-T4	7 (10.6)	59 (89.4)
pN stage, n (%)			0.009
N0	16 (45.7)	12 (18.2)
N1-N3	19 (54.3)	54 (81.8)
Metastasis, n (%)			0.032
M0	35 (100.0)	58 (87.9)
M1	0 (0.0)	8 (12.1)
Tumor size, n (%)			0.626
< 5	15 (42.9)	25 (37.9)
≥ 5	20 (57.1)	41 (62.1)
Tumor location, n (%)			0.611
Antrum	14 (40.0)	33 (50.0)
Body	9 (25.7)	13 (19.7)
Cardia	12 (34.3)	20 (30.3)
Venous invasion, n (%)			0.012
Negative	9 (25.7)	5 (7.6)
Positive	26 (74.3)	61 (92.4)
Neural invasion, n (%)			0.736
Negative	15 (42.9)	26 (39.4)
Positive	20 (57.1)	40 (60.6)
Lymphatic invasion, n (%)			0.001
Negative	22 (62.9)	12 (18.2)
Positive	13 (37.1)	54 (81.8)
Positive lymph node, n (%)			0.001
Negative	22 (62.9)	14 (21.2)
Positive	13 (37.1)	52 (78.8)
Differentiated degree, n (%)			0.16
Poorly	27 (77.1)	58 (87.9)
Moderately and highly	8 (22.9)	8 (12.1)
Lauren’s Classification, n (%)			0.569
Intestinal	23 (65.7)	47 (71.2)
Diffuse	12 (34.3)	19 (28.8)

pT stage: Pathological assessment of primary tumor; pN stage: Pathological assessment of regional lymph nodes; TNM: Tumor-node-metastasis.