Plasma exosomal hsa_circ_0079439 as a novel biomarker for early detection of gastric cancer

Figure 5 Diagnostic value and expression levels of exosomal hsa_circ_0079439, carcinoembryonic antigen, carbohydrate antigen 19-9, carbohydrate antigen 72-4, alpha-fetoprotein, and carbohydrate antigen 125 in total participants for gastric cancer. A: Absolutely quantitative detection of exosomal hsa_circ_0079439 copy number in plasma from healthy donors (HDs) (n = 63) and gastric cancer (GC) patients (n = 240) by droplet digital polymerase chain reaction; B-F: Expression levels of standard serum biomarkers in GC patients and HDs, including carcinoembryonic antigen (B), carbohydrate antigen (CA)19-9 (C), CA72-4 (D), alpha-fetoprotein (E), and CA125 (F); G: Receiver operating characteristic curves of hsa_circ_0079439, carcinoembryonic antigen, CA19-9, CA72-4, alpha-fetoprotein, and CA125 in distinguish GC patients (n = 240) from HDs (n = 63); H: Changes of expression levels of exosomal hsa_circ_0079439 before and after treatment. And all the results are shown as the mean (SD). ^aP < 0.05, ^bP < 0.0001, NS: Not significant. HD: Healthy donor; GC: Gastric cancer; CEA: Carcinoembryonic antigen; CA19-9: Carbohydrate antigen 19-9; CA72-4: Carbohydrate antigen 72-4; CA 125: Carbohydrate antigen 125; AFP: Alpha-fetoprotein.