Mechanism of annexin A1/N-formylpeptide receptor regulation of macrophage function to inhibit hepatic stellate cell activation through Wnt/β-catenin pathway

Figure 5 Annexin A1 inhibits hepatic stellate cell activation. A: Changes in α-smooth muscle actin expression in hepatic stellate cell; B: Connective tissue growth factor mRNA was quantified using quantitative real-time polymerase chain reaction; C: Collagen I mRNA expression. GAPDH was used as an internal control. ^aP < 0.05 and ^bP < 0.01 vs controls; ^cP < 0.05 vs lipopolysaccharide; ^dP < 0.05 and ^eP < 0.01 vs lipopolysaccharide + Ac2-26 (n = 8). AnxA1: Annexin A1; α-SMA: α-smooth muscle actin; HSC: Hepatic stellate cell; CTGF: Connective tissue growth factor; LPS: Lipopolysaccharide; Ac2-26: Active N-terminal peptide of AnxA1; Boc2: N-formyl peptide receptor antagonist N-Boc-Phe-Leu-Phe-Leu-Phe.