Per-oral endoscopic myotomy is safe and effective for pediatric patients with achalasia: A long-term follow-up study

doi:10.3748/wjg.v29.i22.3497

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Jun 14, 2023 (publication date) through Nov 23, 2024

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World Journal of Gastroenterology

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1007-9327

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Retrospective Cohort Study

World J Gastroenterol. Jun 14, 2023; 29(22): 3497-3507
Published online Jun 14, 2023. doi: 10.3748/wjg.v29.i22.3497

Table 1 General characteristics of the pediatric group and the control group

		Pediatric group (n = 48)	Control group (n = 1025)	P value
Sex, n (%)
Male		26 (54.2)	469 (45.8)	0.253
Female		22 (45.8)	556 (54.2)
Age, median (range), years		16 (7-18)	43 (19-65)	< 0.001
BMI, median (range), kg/m²		17.7 (11.2-26.8)	20.9 (12.9-40.4)	< 0.001
Chicago classification, n (%)		n = 42, 87.5	n = 1003, 97.8	0.928
	Type I	7 (16.7)	156 (15.5)
	Type II	32 (76.2)	787 (78.5)
	Type III	3 (7.1)	60 (6.0)
Ling classification, n (%)				0.076
	Ling I	9 (18.8)	189 (17.0)
	Ling IIa	17 (35.4)	340 (30.6)
	Ling IIb	18 (37.5)	249 (22.4)
	Ling IIc	4 (8.3)	206 (18.5)
	Ling III	0 (0.0)	41 (1.35)
Disease course, median (range), month		17.5 (2-120)	48 (1-540)	< 0.001
LES pressure, median (range), mmHg		n = 42, 87.5	n = 1003, 97.8	0.214
LES pressure, median (range), mmHg		25.8 (8.4-65.9)	24.5 (1-83.2)	0.214
Prior treatment				0.210
Patients without prior treatment, n (%)		36 (75.0)	842 (82.1)
Patients with prior treatment, n (%)		12 (25.0)	183 (17.9)
	BTI	4 (8.3)	46 (4.5)
	PBD	5 (10.4)	92 (9.0)
	POEM	1 (2.1)	9 (0.9)
	LHM	0 (0.0)	10 (1.0)
	ESP	0 (0.0)	14 (1.4)
	PBD + BTI	1 (2.1)	3 (0.3)
	ESP + BTI	1 (2.1)	1 (0.1)
	POEM + PBD	0 (0.0)	2 (0.2)
	PBD + ESP	0 (0.0)	3 (0.3)
	PBD + LHM	0 (0.0)	1 (0.1)
	BTI + LHM	0 (0.0)	1 (0.1)
	ESP + LHM	0 (0.0)	1 (0.1)

BTI: Botulinum toxin injection; BMI: Body mass index; PBD: Pneumatic balloon dilation; POEM: Per-oral endoscopic myotomy; LHM: Laparoscopic Heller myotomy; ESP: Endoscopic stent placement; LES: Lower esophageal sphincter.

Citation: Bi YW, Lei X, Ru N, Li LS, Wang NJ, Zhang B, Yao Y, Linghu EQ, Chai NL. Per-oral endoscopic myotomy is safe and effective for pediatric patients with achalasia: A long-term follow-up study. World J Gastroenterol 2023; 29(22): 3497-3507
URL: https://www.wjgnet.com/1007-9327/full/v29/i22/3497.htm
DOI: https://dx.doi.org/10.3748/wjg.v29.i22.3497